7 Best Herbs for Everyday Pain to Support Additional Pain Relief and Restore Balance*

7 Best Herbs for Everyday Pain to Support Additional Pain Relief and Restore Balance*
7 Best Herbs for Everyday Pain to Support Additional Pain Relief and Restore Balance*

Everyday pain can disrupt your daily life and prevent you from doing the things you love. It’s your body’s way of telling you that you may have overdone it — but that doesn’t mean you have to suffer. Try adding herbs that are traditionally used to help relieve common, everyday pain to your routine.*

Taking herbal supplements can go a long way toward supporting an active lifestyle and minimizing the pain that is due to normal daily wear and tear.*

In this article, we discuss the best herbs for pain and tell you everything you need to know so you can choose the one that’s right for you.

The Best Herbs for Pain*

1) Turmeric

Traditional Uses

Turmeric has been used for thousands of years in Southeastern and Eastern Asia as a traditional medicine and spice.* In fact, reports of its use as an herb to help reduce occasional inflammation due to normal daily wear and tear go as far back as 600 B.C.1

Turmeric in combination with other herbs may also help support:*

How to Take It 

 Gaia Herbs Turmeric Supreme Pain

You can add a teaspoon of Turmeric to soups, sauces, or smoothies. Adding culinary Turmeric is beneficial and we recommend including it in your diet. As a food, Turmeric supports your ojas (vital energy), and, being a bitter herb, it supports digestion, too.*

However, Turmeric root powder as a food ingredient /spice doesn’t offer the same targeted support that a supplement does. The fat-soluble active components of Turmeric, including its essential oils, need to pass the blood-brain barrier to offer targeted support in the body.*

In culinary uses, these essential oils are not preserved (cooking only releases their aroma and flavor) or not available (most uncooked preparations do not support the absorption of those fat-soluble components), and the potency of dried Turmeric diminishes over time.

For an even easier way to reduce occasional inflammation due to overactivity and to support a healthy inflammatory response, try Gaia Herbs Turmeric Supreme Pain.* No measuring spoons. No recipes. Just easy-to-take Liquid Phyto-Caps® for a Turmeric boost any time, day or night.

If you’re interested in learning more about our herbal supplements, we’ve got you covered. Here at Gaia Herbs, we are committed to transparency and want you to know what’s in the supplements you’re taking.

That’s why we created Meet Your Herbs®, the world’s first herb traceability platform. There, you’ll discover the origin of your herbs, learn how they were grown, and see validation of your product’s level of purity and potency.

We verify at every stage of the Gaia Herbs seed-to-shelf journey — because you deserve to know exactly what’s in your herbal supplement.

2) Ginger 

Traditional Uses

Ask any Ayurvedic professional and you’ll find that Ginger is highly recommended. In fact, it’s one of the most widely consumed aromatic spices on the planet.

The Ginger plant — a member of the Zingiberaceae family — originally grew wild in the tropical climate of Asia, but it is now successfully grown as a food crop in the Caribbean and Africa.

Ginger is considered a good choice to help manage common pain because it helps support a normal inflammatory system and a healthy immune response.*2

Ginger in combination with other herbs may also help support:*

How to Take It

Gaia Herbs Ginger Supreme herbal supplement

Like Turmeric, Ginger is easy to add to your favorite recipes. But for an even simpler way to incorporate Ginger into your balanced diet, try Gaia Herbs Ginger Supreme herbal supplement.

3) Clove

Traditional Uses

Another herb for common, everyday pain is Clove. Cloves are the dried buds of the Syzygium aromaticum tree, an evergreen in the Myrtaceae family that is native to Indonesia.

Clove has been an important herb in Indian cooking for hundreds of years. You’ll find it in spice blends such as garam masala and biryani. You’ll also find it in masala chai, which is a key ingredient in Chai Tea.

Clove became so popular in seventeenth- and eighteenth-century Britain that it was valued almost as much as gold and was one of several reasons that merchants and royalty alike sought to improve trade routes with South East Asia.

Like many of the other herbs for pain on this list, Clove supports a healthy immune system and is believed to support a healthy inflammatory response, which can help manage the symptoms you feel when something is out of balance in your body.*3

The high amount of Eugenol essential oil in the dried flower bud is responsible for the highly aromatic characteristics and the "numbing" sensation it has been reported to provide.*

Clove in combination with other herbs may also help support:*

How to Take It

Gaia Herbs Wormwood Black Walnut Supreme made with herbs for pain

Today, chefs still use cloves as a way to enhance the flavor and aroma in their dishes. But to experience the benefits of this common herb in supplement form, try Gaia Herbs Wormwood Black Walnut Supreme, which includes Clove in it, or search for Clove in our herb reference guide.

4) Feverfew

Traditional Uses

We’ve included Feverfew — also called featherfew and bachelor’s buttons — on this list of herbs for pain because people have been traditionally using it for years as a treatment for occasional fevers, headaches, stiffness, toothaches, and stomachaches, and for the occasional common pain experienced from increased activity — such as a work out.*

Feverfew is a member of the Asteraceae family, along with the daisy, and is native to the Balkan Mountains of Eastern Europe.

The ancient Greeks even used Feverfew (then called Parthenium) in their medical remedies. As legend has it, Feverfew was used to save the life of an unfortunate individual who fell from the Parthenon on the acropolis in Athens.

Feverfew in combination with other herbs may also help support:*

How to Take It

Gaia Herbs Turmeric Supreme Pain P.M with herbs for pain

Feverfew has some strong side effects if taken in too high a dosage, so be sure to talk to a doctor or Ayurvedic professional before adding it to your routine, and always follow product instructions.4

For nighttime comfort of occasional pain, try Gaia Herbs Turmeric Supreme Pain P.M..*

5) Rosemary

Traditional Uses

Rosemary is another one of the herbs on this list that has been used for thousands of years.

The Rosemary plant — derived from the Latin for “dew (ros) and “sea” (marinus) — is a member of the mint family and is native to the Mediterranean regions in and around Greece.

Before refrigeration — and even after — chefs and farmers in milder climates used Rosemary as a preservative, along with Oregano and Thyme, to keep meat fresh longer during the summer months.

Rosemary contains antioxidants that are believed to help support a healthy inflammatory response in healthy individuals when your body is out of balance, which is why many believe this is a good herb to turn to in order to help manage and provide additional relief of occasional aches and pains.*5

Rosemary in combination with other herbs may also help support:*

How to Take It

This powerful plant can be found in our Turmeric Supreme Pain that we mentioned earlier, as well as other herbal supplements for various health concerns.*

6) Boswellia

Traditional Uses

Boswellia serrata trees — from which the herb gets its name — grow in the dry, mountainous climates of India, the Middle East, and Northern Africa.

As an herb for pain, Boswellia (a.k.a. Indian Frankincense) has been used by Ayurvedic practitioners for many years as a traditional support for occasional pain.*6

Boswellia in combination with other herbs may also help support:

How to Take It

Gaia Herbs Turmeric Supreme Joint with herbs for pain

To incorporate Boswellia into your diet and support joint health, try Gaia Herbs Turmeric Supreme Joint so you can keep enjoying your active lifestyle.*

7) Aloe Vera 

Traditional Uses

Aloe is one of the most common health plants in homes across the country and is a welcome addition to this list of herbs for pain.

The Aloe plant is native to the warm climates of Southern Africa but is also successfully grown in hot, dry regions such as the Rio Grande Valley of Texas.

Although Aloe Vera grows best with minimal water and lots of sun, the root can survive freezing temperatures as long as the ground does not freeze and the root remains undamaged.

This plant is ideal for supporting healthy mucous membranes and maintaining hydrated skin.* In combination with other herbs, it may also help support:*

How to Take It

Gaia Herbs Sage & Aloe Herbal Throat Lozenges

Aloe Vera products are made from the juice of the plant, the gel inside, and the leaf itself. You can take this herb as a tablet, a capsule, a juice, a gel, a topical ointment, or a lotion.

As with other herbs, the part of the plant used often determines the benefits you’ll receive. For example, Aloe gel and juice are considered demulcent and have soothing properties for the skin.*

On the other hand, preparations using the whole Aloe leaf, which contains a group of immune-supportive plant chemicals called polysaccharides (not found in the inner gel or juice), are traditionally known to support the body's natural elimination processes and to help maintain the intestinal tract, mucous membranes, and skin.*

To support a clear and healthy throat, try Gaia Herbs Sage & Aloe Herbal Throat Lozenges.* And to help cool occasional heartburn and relieve indigestion, try Gaia Herbs Reflux Relief.*

Seek Guidance for the Best Herbs for Pain*

It’s important to talk to your doctor before adding herbs to help support additional pain relief to your wellness routine.* While herbs may be able to help reduce the occasional common aches and pains that come with your daily activity, for more serious conditions, you will likely need more serious treatment.*

To make sure you are using the best herbs for pain for your specific concerns, it’s also a good idea to consult an Ayurvedic professional or Naturopathic doctor. They can provide you with more information, guidance, and advice on how to combine multiple herbs to achieve the best results. They can also give you instructions for adding herbs to your balanced diet.*

Be sure to always follow dosing instructions and take your herbs at the proper time of the day — energizing herbs in the morning, calming herbs in the evening — so you don’t disrupt your natural circadian rhythms.

To shop herbs for pain, search for our products by herb or by health interest or enter your zip code on our Where to Buy page to find a store near you that carries Gaia Herbs products.

REFERENCES:

1 Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz.
https://www.scielo.br/pdf/mioc/v96n5/v96n5a26.pdf

2 Volatile aroma constituents of Sri Lankan ginger. Phytochemistry.
https://www.sciencedirect.com/science/article/abs/pii/S0031942200803325#:~:text=Analysis%20by%20GC%20and%20GC,%2C%20%CE%B4%2Dcadinene%20and%20farnesol.

3 Herbal Medicine: A Guide for Healthcare Professionals. The Pharmaceutical Press.
https://pubs.acs.org/doi/full/10.1021/np0207320

4 Herbal medicines in migraine prevention Randomized double-blind placebo-controlled crossover trial of a feverfew preparation. Phytomedicine.
https://pubmed.ncbi.nlm.nih.gov/23195074/

5 Ethnobotany and ethnopharmacology--interdisciplinary links with the historical sciences. Journal of Ethnopharmacology.
https://pubmed.ncbi.nlm.nih.gov/16876349/

6 Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb. Indian Journal of Experimental Biology.
https://pubmed.ncbi.nlm.nih.gov/15320503/

7 Implications for degenerative disorders: antioxidative activity, total phenols, flavonoids, ascorbic acid, beta-carotene and beta-tocopherol in Aloe vera. Oxidative Medicine and Cellular Longevity.
https://pubmed.ncbi.nlm.nih.gov/20357932/

REFERENCES:

  • 1. Gustavo F. Gonzales, "Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands", Journal List Evid Based Complement Alternat Med v.2012; 2012 PMC3184420. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184420/
  • 2. Luis G Valerio Jr, Gustavo F Gonzales, "Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis", Toxicol Rev . 2005;24(1):11-35. doi: 10.2165/00139709-200524010-00002. PMID: 16042502. https://pubmed.ncbi.nlm.nih.gov/16042502/
  • 3. H. O. Meissner,1 P. Mrozikiewicz,2 T. Bobkiewicz-Kozlowska,3 A. Mscisz,2 B. Kedzia,2 A. Lowicka,2 H. Reich-Bilinska,4 W. Kapczynski,5 and I. Barchia6, "Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (I) Biochemical and Pharmacodynamic Study on Maca using Clinical Laboratory Model on Ovariectomized Rats", Journal List Int J Biomed Sci v.2(3); 2006 Sep PMC3614604. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614604/
  • 4. Eva Fries 1, Lucia Dettenborn, Clemens Kirschbaum, "The cortisol awakening response (CAR): facts and future directions", Int J Psychophysiol. 2009 Apr;72(1):67-73. doi: 10.1016/j.ijpsycho.2008.03.014.Epub 2008 Sep 30.. https://pubmed.ncbi.nlm.nih.gov/18854200/
  • 5. Nicolas C. Nicolaides 1, Alexandros N. Vgontzas 2, Ilia Kritikou 3, George Chrousos 4 Kenneth R Feingold 1, Bradley Anawalt 2, Alison Boyce 3, George Chrousos 4, Wouter W de Herder 5, Ketan Dhatariya 6, Kathleen Dungan 7, Jerome M Hershman 8, Johannes Hofland 9, Sanjay Kalra 10, Gregory Kaltsas 11, Christian Koch 12, Peter Kopp 13, Márta Korbonits 14, Christopher S Kovacs 15, Wendy Kuohung 16, Blandine Laferrère 17, Miles Levy 18, Elizabeth A McGee 19, Robert McLachlan 20, John E Morley 21, Maria New 22, Jonathan Purnell 23, Rakesh Sahay 24, Frederick Singer 25, Mark A Sperling 26, Constantine A Stratakis 27, Dace L Trence 28, Don P Wilson 29 , editors., "HPA Axis and Sleep", PMID: 25905298 Bookshelf ID: NBK279071. https://pubmed.ncbi.nlm.nih.gov/25905298/
  • 6. José Manuel Lozano Sánchez', Zoraida Axtle Serranol*, Julio Avilés Durán, Héctor Salvador Godoy Morales, Paola Berenice Merchand Álvarez, Ricardo Mera Mejía? Luis Felipe Montaño Estrada and Erika Patricia Rendón Huerta, "Peruvian Maca and Possible Impact on Fertility", Journal of Nutritional Health & Food Engineering. https://www.researchgate.net/profile/Jose-Manuel-Lozano-Sanchez/publication/317569911_Peruvian_Maca_and_Possible_Impact_on_Fertility/links/59494b03aca272a30c6cae11/Peruvian-Maca-and-Possible-Impact-on-Fertility.pdf
  • 7. A López-Fando 1, M P Gómez-Serranillos, I Iglesias, O Lock, U P Upamayta, M E Carretero, "Lepidium peruvianum chacon restores homeostasis impaired by restraint stress", Phytother Res . 2004 Jun;18(6):471-4. doi: 10.1002/ptr.1455.. https://pubmed.ncbi.nlm.nih.gov/15287072/
  • 8. Gustavo F. Gonzales *, "Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands", Evid Based Complement Alternat Med. 2012; 2012: 193496. Published online 2011 Oct 2. doi: 10.1155/2012/193496. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184420/
  • 9. José Manuel Lozano Sánchez', Zoraida Axtle Serranol*, Julio Avilés Durán, Héctor Salvador Godoy Morales, Paola Berenice Merchand Álvarez, Ricardo Mera Mejía? Luis Felipe Montaño Estrada and Erika Patricia Rendón Huerta, "Peruvian Maca and Possible Impact on Fertility", Journal of Nutritional Health & Food Engineering. https://www.researchgate.net/profile/Jose-Manuel-Lozano-Sanchez/publication/317569911_Peruvian_Maca_and_Possible_Impact_on_Fertility/links/59494b03aca272a30c6cae11/Peruvian-Maca-and-Possible-Impact-on-Fertility.pdf
  • 10. Maria Rosales-Hartshorn*, "Maca: Botanical Medicine from the Andes", Volume 1 : Issue 2 Article Ref. #: 1000AFTNSOJ1e001. https://www.openventio.org/Volume1-Issue2/Maca-Botanical-Medicine-from-the-Andes-AFTNSOJ-1-e001.pdf
  • 11. Natália da Silva Leitão Peres 1, Letícia Cabrera Parra Bortoluzzi, Leila Larisa Medeiros Marques, Maysa Formigoni, Renata Hernandez Barros Fuchs, Adriana Aparecida Droval, Flávia Aparecida Reitz Cardoso, "Medicinal effects of Peruvian maca (Lepidium meyenii): a review", Food Funct. 2020 Jan 29;11(1):83-92. doi: 10.1039/c9fo02732g.. https://pubmed.ncbi.nlm.nih.gov/31951246/
  • 12. Office of Communications, "How common is infertility?", Home- Health- A to Z List- Infertility and Fertility- About- How common is infertility?. https://www.nichd.nih.gov/health/topics/infertility/conditioninfo/common#f1
  • 13. ASRM, American Society for Reproductive Medicine., "In approximately 40 percent of infertile couples, the male partner is either the sole cause or a contributing cause of infertility", Home Infographic Gallery. https://www.reproductivefacts.org/resources/infographic-gallery/images/in-approximately-40-percent-of-infertile-couples-the-male-partner-is-either-the-sole-cause-or-a-contributing-cause-of-infertility/
  • 14. G F Gonzales 1, A Cordova, C Gonzales, A Chung, K Vega, A Villena, "Lepidium meyenii (Maca) improved semen parameters in adult men", Asian J Androl. 2001 Dec;3(4):301-3.. https://pubmed.ncbi.nlm.nih.gov/11753476/
  • 15. José Manuel Lozano Sánchez', Zoraida Axtle Serranol*, Julio Avilés Durán, Héctor Salvador Godoy Morales, Paola Berenice Merchand Álvarez, Ricardo Mera Mejía? Luis Felipe Montaño Estrada and Erika Patricia Rendón Huerta, "Peruvian Maca and Possible Impact on Fertility", DOI:10.15406/jnhfe.2017.06.00217. https://www.researchgate.net/publication/317569911_Peruvian_Maca_and_Possible_Impact_on_Fertility
  • 16. Daniel Nedresky; Gurdeep Singh., "Physiology, Luteinizing Hormone", Treasure Island (FL): StatPearls Publishing; 2022 Jan-.. https://www.ncbi.nlm.nih.gov/books/NBK539692/
  • 17. G F Gonzales 1, A Cordova, C Gonzales, A Chung, K Vega, A Villena, "Lepidium meyenii (Maca) improved semen parameters in adult men", Asian J Androl. 2001 Dec;3(4):301-3.. https://pubmed.ncbi.nlm.nih.gov/11753476/
  • 18. G F Gonzales, M Gasco, A Córdova, A Chung, J Rubio and L Villegas, "Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m)", Instituto de Investigaciones de la Altura, and Departamento de Ciencias Biolo´gicas y Fisiolo´gicas Facultad de Ciencas y Filosofı´a, Universidad Peruana Cayetano Heredia, PO Box 1843, Lima, Peru (Requests for offprints should be addressed to G F Gonzales, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, PO Box 1843, Lima, Peru; Email: iiad@upch.edu.pe). http://eplant.njau.edu.cn/maca/publication/Effect%20of%20Lepidium%20meyenii%20(Maca)%20on%20spermatogenesis%20in%20male%20rats%20acutely%20exposed%20to%20high%20altitude%20(4340%20m).pdf
  • 19. A López-Fando, M P Gómez-Serranillos, I Iglesias, O Lock, U P Upamayta, M E Carretero, "Lepidium peruvianum chacon restores homeostasis impaired by restraint stress", Phytother Res . 2004 Jun;18(6):471-4. doi: 10.1002/ptr.1455.. https://pubmed.ncbi.nlm.nih.gov/15287072/
  • 20. G. F. Gonzales,A. Córdova,K. Vega,A. Chung,A. Villena,C. Góñez,S. Castillo, "Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men", Journal of Andrology. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1439-0272.2002.00519.x
  • 21. Byung-Cheul Shin, Myeong Soo Lee, Eun Jin Yang, Hyun-Suk Lim, Edzard Ernst, "Maca (L. meyenii) for improving sexual function: a systematic review", BMC Complement Altern Med . 2010 Aug 6;10:44. doi: 10.1186/1472-6882-10-44.. https://pubmed.ncbi.nlm.nih.gov/20691074/
  • 22. José Manuel Lozano Sánchez, Zoraida Axtle, Julio Aviles, Héctor Salvador Godoy Morales, Paola Berenice Merchand Álvarez, Ricardo Mera Mejía, Luis Felipe Montaño Estrada, Erika Patricia Rendón Huerta, "Peruvian Maca and Possible Impact on Fertility", Journal of Nutritional Health & Food Engineering. https://www.researchgate.net/publication/317569911_Peruvian_Maca_and_Possible_Impact_on_Fertility
  • 23. Hongkang Zhu, Wenqian Xu, Ning Wang, Wenhao Jiang, Yuliang Cheng, Yahui Guo, Weirong Yao, Bin Hu, Peng Du and He Qian, "Anti-fatigue effect of Lepidium meyenii Walp. (Maca) on preventing mitochondria-mediated muscle damage and oxidative stress in vivo and vitro†", Journal of Food & Function. https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo00383f/unauth
  • 24. Mark Stone, Alvin Ibarra, Marc Roller, Andrea Zangara, Emma Stevenson, "A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen", J Ethnopharmacol . 2009 Dec 10;126(3):574-6. doi: 10.1016/j.jep.2009.09.012. Epub 2009 Sep 23.. https://pubmed.ncbi.nlm.nih.gov/19781622/
  • 25. Gustavo F Gonzales, Sara Miranda, Jessica Nieto, Gilma Fernández, Sandra Yucra, Julio Rubio, Pedro Yi & Manuel Gasco, "Red maca (Lepidium meyenii) reduced prostate size in rats", Reprod Biol Endocrinol 3, 5 (2005). https://doi.org/10.1186/1477-7827-3-5. https://rbej.biomedcentral.com/articles/10.1186/1477-7827-3-5
  • 26. C Gonzales, J Leiva-Revilla, J Rubio, M Gasco, G F Gonzales, "Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia", Andrologia . 2012 May;44 Suppl 1:362-9. doi: 10.1111/j.1439-0272.2011.01190.x. Epub 2011 Jul 18.. https://pubmed.ncbi.nlm.nih.gov/21762188/
  • 27. G. F. Gonzales,A. Córdova,K. Vega,A. Chung,A. Villena,C. Góñez,S. Castillo, "Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men", Journal of Andrology. https://onlinelibrary.wiley.com/doi/full/10.1046/j.1439-0272.2002.00519.x
  • 28. Y Ohta, N Kawate, T Inaba, H Morii, K Takahashi, H Tamada, "Feeding hydroalcoholic extract powder of Lepidium meyenii (maca) enhances testicular gene expression of 3β-hydroxysteroid dehydrogenase in rats", Andrologia . 2017 Dec;49(10). doi: 10.1111/and.12792. Epub 2017 Mar 6.. https://pubmed.ncbi.nlm.nih.gov/28261840/
  • 29. Ángel Rodríguez-Huamán, Sandra Casimiro-Gonzales, Jorge Antonio Chávez-Pérez, Carla Gonzales-Arimborgo, Richard Cisneros-Fernández, Luis Ángel Aguilar-Mendoza, Gustavo F Gonzales, "Antioxidant and neuroprotector effect of Lepidium meyenii (maca) methanol leaf extract against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells", Toxicol Mech Methods . 2017 May;27(4):279-285. doi: 10.1080/15376516.2016.1275908. Epub 2017 Jan 8.. https://pubmed.ncbi.nlm.nih.gov/28007001/
  • 30. Bárbara Teixeira, António Marques, Cristina Ramos, Maria Carmo Serrano, Olívia Matos, Nuno R Neng, José Nogueira, Jorge M. A. Saraiva, Maria Leonor Nunes, "Chemical composition and bioactivity of different oregano (Origanum vulgare) extracts and essential oil", Journal of the Science of Food and Agriculture 93(11) DOI:10.1002/jsfa.6089. https://www.researchgate.net/publication/236104725_Chemical_composition_and_bioactivity_of_different_oregano_Origanum_vulgare_extracts_and_essential_oil
  • 31. Wesam Kooti, Zahra Hasanzadeh-Noohi, Naim Sharafi-Ahvazi, Majid Asadi-Samani, Damoon Ashtary-Larky, "Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa)", Chin J Nat Med . 2016 Oct;14(10):732-745. doi: 10.1016/S1875-5364(16)30088-7. Epub 2016 Oct 31.. https://pubmed.ncbi.nlm.nih.gov/28236403/
  • 32. Łukasz Łuczaj & Wojciech M Szymański, "Wild vascular plants gathered for consumption in the Polish countryside: a review.", Journal of Ethnobiology and Ethnomedicine volume 3, Article number: 17 (2007). https://ethnobiomed.biomedcentral.com/articles/10.1186/1746-4269-3-17
  • 33. IKHLAS A. KHAN, EHAB A. ABOURASHED, "Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics.", John Wiley & Sons, Inc., Hoboken, New Jersey. https://naturalingredient.org/wp/wp-content/uploads/leungs-encyclopedia-of-common-natural-ingredients-3rd-edition.pdf
  • 34. Adom MB, Taher M, Mutalabisin MF, Amri MS, Abdul Kudos MB, Wan Sulaiman MWA, Sengupta P, Susanti D, "Chemical constituents and medical benefits of Plantago major.", Biomedecine & Pharmacotherapie, 10 Oct 2017, 96:348-360 DOI: 10.1016/j.biopha.2017.09.152 PMID: 29028587. https://europepmc.org/article/med/29028587#similar-articles
  • 35. ZOT Organic, "What is Licorice?", General Info. https://zotorganic.com/information/licorice/#:~:text=The%20plant%20is%20prized%20for,shrub%2C%20is%20officially%20a%20weed.
  • 36. Dalia Akramiene, Anatolijus Kondrotas, Janina Didziapetriene, Egidijus Kevelaitis, "Effects of beta-glucans on the immune system", Medicina (Kaunas) . 2007;43(8):597-606.. https://pubmed.ncbi.nlm.nih.gov/17895634/
  • 37. R C Rosen, "Prevalence and risk factors of sexual dysfunction in men and women", Curr Psychiatry Rep . 2000 Jun;2(3):189-95. doi: 10.1007/s11920-996-0006-2.. https://pubmed.ncbi.nlm.nih.gov/11122954/
  • 38. Natália da Silva Leitão Peres, Letícia Cabrera Parra Bortoluzzi, Leila Larisa Medeiros Marques, Maysa Formigoni, Renata Hernandez Barros Fuchs, Adriana Aparecida Droval, Flávia Aparecida Reitz Cardoso, "Medicinal effects of Peruvian maca (Lepidium meyenii): a review", Food Funct . 2020 Jan 29;11(1):83-92. doi: 10.1039/c9fo02732g.. https://pubmed.ncbi.nlm.nih.gov/31951246/
  • 39. Nicole A Brooks, Gisela Wilcox, Karen Z Walker, John F Ashton, Marc B Cox, Lily Stojanovska, "Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content", Menopause . 2008 Nov-Dec;15(6):1157-62. doi: 10.1097/gme.0b013e3181732953.. https://pubmed.ncbi.nlm.nih.gov/18784609/
  • 40. Maria Rosales-Hartshorn*, "Maca: Botanical Medicine from the Andes", Adv Food Technol Nutr Sci Open J. 2015; 1(2): e1-e6. doi: 10.17140/AFTNSOJ-1-e001. https://www.openventio.org/Volume1-Issue2/Maca-Botanical-Medicine-from-the-Andes-AFTNSOJ-1-e001.pdf
  • 41. Sánchez JML, Serrano ZA, Durán JA, Morales HSG, Álvarez PBM (2017), "Peruvian Maca and Possible Impact on Fertility", J Nutr Health Food Eng 6(5): 00217. DOI: 10.15406/jnhfe.2017.06.00217. https://www.researchgate.net/profile/Jose-Manuel-Lozano-Sanchez/publication/317569911_Peruvian_Maca_and_Possible_Impact_on_Fertility/links/59494b03aca272a30c6cae11/Peruvian-Maca-and-Possible-Impact-on-Fertility.pdf
  • 42. Leila Mazaheri Nia, Mina Iravani, Parvin Abedi, Bahman Cheraghian, "Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial", J Sex Marital Ther . 2021;47(8):804-813. doi: 10.1080/0092623X.2021.1957732. Epub 2021 Jul 27.. https://pubmed.ncbi.nlm.nih.gov/34311679/
  • 43. G. F. Gonzales,A. Córdova,K. Vega,A. Chung,A. Villena,C. Góñez,S. Castillo, "Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men", Journal of Andrology. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1439-0272.2002.00519.x
  • 44. Byung-Cheul Shin 1, Myeong Soo Lee, Eun Jin Yang, Hyun-Suk Lim, Edzard Ernst, "Maca (L. meyenii) for improving sexual function: a systematic review", BMC Complement Altern Med . 2010 Aug 6;10:44. doi: 10.1186/1472-6882-10-44.. https://pubmed.ncbi.nlm.nih.gov/20691074/
  • 45. Ghanbarali Raeis Jalali, Jamshid Roozbeh, Azam Mohammadzadeh, Maryam Sharifian, Mohammad Mahdi Sagheb, Alireza Hamidian Jahromi, Sanaz Shabani, Fariborz Ghaffarpasand, Raha Afshariani, "Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis", Ren Fail . 2010 May;32(4):417-9. doi: 10.3109/08860221003706958.. https://pubmed.ncbi.nlm.nih.gov/20446777/
  • 46. Tahoora Shomali, Mahnaz Taherianfard, Maryam Dalvand, Fatemeh Namazi, "Effect of pharmacological doses of niacin on testicular structure and function in normal and diabetic rats", Andrologia . 2018 Dec;50(10):e13142. doi: 10.1111/and.13142. Epub 2018 Sep 6.. https://pubmed.ncbi.nlm.nih.gov/30191583/
  • 47. Gonzales G. F., Cordova A., Gonzales C., Chung A., Vega K., Villena A., "Lepidium meyenii (Maca) improved semen parameters in adult men.", Asian Journal of Andrology. 2001;3(4):301–303.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411442/#B19
  • 48. Bogani P., Simonini F., Iriti M., et al., "Lepidium meyenii (Maca) does not exert direct androgenic activities.", Journal of Ethnopharmacology. 2006;104(3):415–417. doi: 10.1016/j.jep.2005.09.028.. ncbi.nlm.nih.gov/pmc/articles/PMC4411442/#B27
  • 49. Gonzalez G. F., Córdova A., Vega K., Chung A., Villena A., Góñez C., "Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing propeties, on serum reproductive hormone levels in adult healthy men.", Journal of Endocrinology. 2003;176(1):163–168. doi: 10.1677/joe.0.1760163.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411442/#B28
  • 50. Christina M. Dording , * Pamela J. Schettler, Elizabeth D. Dalton, Susannah R. Parkin, Rosemary S. W. Walker, Kara B. Fehling, Maurizio Fava, and David Mischoulon, "A Double-Blind Placebo-Controlled Trial of Maca Root as Treatment for Antidepressant-Induced Sexual Dysfunction in Women", Journal List Evid Based Complement Alternat Med v.2015; 2015 PMC4411442. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411442/
  • 51. Srikugan L., Sankaralingam A., McGowan B., "First case report of testosterone assay-interference in a female taking maca (Lepidium meyenii) BMJ Case Reports.", 2011 doi: 10.1136/bcr.01.2011.3781.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411442/#B26
  • 52. Olivia Remes,Carol Brayne,Rianne van der Linde,Louise Lafortune, "A systematic review of reviews on the prevalence of anxiety disorders in adult populations", Journal of Brain and Behavior, 05 June 2016. https://onlinelibrary.wiley.com/doi/10.1002/brb3.497
  • 53. Rohit Verma, Yatan Pal Singh Balhara, and Chandra Shekhar Gupta, "Gender differences in stress response: Role of developmental and biological determinants", Journal List Ind Psychiatry J v.20(1); Jan-Jun 2011 PMC3425245. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425245/
  • 54. Mohammad Hossein Mirjalili, Elisabeth Moyano, Mercedes Bonfill, Rosa M Cusido, Javier Palazón, "Steroidal lactones from Withania somnifera, an ancient plant for novel medicine", Molecules . 2009 Jul 3;14(7):2373-93.. https://pubmed.ncbi.nlm.nih.gov/19633611/
  • 55. R C Rosen, "Prevalence and risk factors of sexual dysfunction in men and women", Curr Psychiatry Rep . 2000 Jun;2(3):189-95. DOI: 10.1007/s11920-996-0006-2.. https://pubmed.ncbi.nlm.nih.gov/11122954/
  • 56. Swati Dongre, Deepak Langade, Sauvik Bhattacharyya, "Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study", Biomed Res Int . 2015;2015:284154. doi: 10.1155/2015/284154.. https://pubmed.ncbi.nlm.nih.gov/26504795/
  • 57. UT NEWS, "Stress Hormone Blocks Testosterone’s Effects, Study Shows", Journal of Science and Technology. https://news.utexas.edu/2010/09/27/stress-hormone-blocks-testosterones-effects-study-shows/
  • 58. Rashad, N.M., Samir, G.M., "Prevalence, risks, and comorbidity of thyroid dysfunction: a cross-sectional epidemiological study", Egypt J Intern Med 31, 635–641 (2019). https://ejim.springeropen.com/articles/10.4103/ejim.ejim_22_19
  • 59. Cleveland Clinic, "Thyroid: What It Is, Function and Problems", Journal of Body Systems & Organs. https://my.clevelandclinic.org/health/body/23188-thyroid
  • 60. Sharma AK, Basu I, Singh S., "Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial", J Altern Complement Med. 2018 Mar;24(3):243-248. doi: 10.1089/acm.2017.0183. Epub 2017 Aug 22. PMID: 28829155.. https://pubmed.ncbi.nlm.nih.gov/28829155/
  • 61. Chandrasekhar K, Kapoor J, Anishetty S., "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults", Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022. PMID: 23439798; PMCID: PMC3573577.. https://pubmed.ncbi.nlm.nih.gov/23439798/
  • 62. Stephens MA, Wand G., "Stress and the HPA axis: role of glucocorticoids in alcohol dependence", Alcohol Res. 2012;34(4):468-83. PMID: 23584113; PMCID: PMC3860380.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860380/
  • 63. Centers for Disease Control and Prevention, "1 in 3 adults don’t get enough sleep", CDC.gov. https://www.cdc.gov/media/releases/2016/p0215-enough-sleep.html
  • 64. Centers for Disease Control and Prevention, "Sleep and Sleep Disorders", CDC.gov. https://www.cdc.gov/sleep/data_statistics.html
  • 65. Krishnan V, Collop NA., "Gender differences in sleep disorders", Curr Opin Pulm Med. 2006 Nov;12(6):383-9. doi: 10.1097/01.mcp.0000245705.69440.6a. PMID: 17053485.. https://pubmed.ncbi.nlm.nih.gov/17053485/
  • 66. Danielle Pacheco, Ealena Callender, "Women and Sleep", Sleep Foundation. https://www.sleepfoundation.org/women-sleep
  • 67. Langade D, Thakare V, Kanchi S, Kelgane S., "Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study", J Ethnopharmacol. 2021 Jan 10;264:113276. doi: 10.1016/j.jep.2020.113276. Epub 2020 Aug 17. PMID: 32818573.. https://pubmed.ncbi.nlm.nih.gov/32818573/
  • 68. Abhijit Deshpande, Nushafreen Irani, Ratna Balkrishnan, Irin Rosanna Benny, "A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults", Sleep Medicine, Volume 72, 2020, Pages 28-36, ISSN 1389-9457,. https://www.sciencedirect.com/science/article/abs/pii/S1389945720301246
  • 69. Mahesh K. Kaushik, Sunil C. Kaul, Renu Wadhwa, Masashi Yanagisawa, Yoshihiro Urade, "Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction", plos.org DOI:10.1371/journal.pone.0172508. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172508#abstract0
  • 70. Auddy B, Hazra J, Mitra A, et al., "A standardized Withania Somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study", J Am Neutraceut Assoc 2008;11:50–6.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/#R20
  • 71. Andrade C, Aswath A, Chaturvedi SK, et al., "A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera", Indian J Psychiatry 2000;42:295–301.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/#R18
  • 72. Fries E, Dettenborn L, Kirschbaum C., "The cortisol awakening response (CAR): facts and future directions", Int J Psychophysiol. 2009 Apr;72(1):67-73. doi: 10.1016/j.ijpsycho.2008.03.014. Epub 2008 Sep 30. PMID: 18854200.. https://pubmed.ncbi.nlm.nih.gov/18854200/
  • 73. Nicolas C. Nicolaides, Alexandros N. Vgontzas, Ilia Kritikou, George Chrousos Kenneth R Feingold, Bradley Anawalt, Alison Boyce, George Chrousos, Wouter W de Herder, Ketan Dhatariya, Kathleen Dungan, Jerome M Hershman, Johannes Hofland, Sanjay Kalra, Gregory Kaltsas, Christian Koch, Peter Kopp, Márta Korbonits, Christopher S Kovacs, Wendy Kuohung, Blandine Laferrère, Miles Levy, Elizabeth A McGee, Robert McLachlan, John E Morley, Maria New, Jonathan Purnell, Rakesh Sahay, Frederick Singer, Mark A Sperling, Constantine A Stratakis, Dace L Trence, Don P Wilson, "HPA Axis and Sleep", In: Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. 2020 Nov 24. PMID: 25905298 Bookshelf ID: NBK279071. https://pubmed.ncbi.nlm.nih.gov/25905298/
  • 74. Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S., "Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study", Phytomedicine. 2000 Dec;7(6):463-9. doi: 10.1016/S0944-7113(00)80030-6. PMID: 11194174.. https://pubmed.ncbi.nlm.nih.gov/11194174/
  • 75. Gopal S, Ajgaonkar A, Kanchi P, Kaundinya A, Thakare V, Chauhan S, Langade D., "Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study", J Obstet Gynaecol Res. 2021 Dec;47(12):4414-4425. doi: 10.1111/jog.15030. Epub 2021 Sep 22. PMID: 34553463.. https://pubmed.ncbi.nlm.nih.gov/34553463/
  • 76. Chandrasekhar K, Kapoor J, Anishetty S., "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.", Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022. PMID: 23439798; PMCID: PMC3573577.. https://pubmed.ncbi.nlm.nih.gov/23439798/
  • 77. Khedgikar V, Kushwaha P, Gautam J, Verma A, Changkija B, Kumar A, Sharma S, Nagar GK, Singh D, Trivedi PK, Sangwan NS, Mishra PR, Trivedi R., "Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone", Cell Death Dis. 2013 Aug 22;4(8):e778. doi: 10.1038/cddis.2013.294. PMID: 23969857; PMCID: PMC3763455.. https://pubmed.ncbi.nlm.nih.gov/23969857/
  • 78. Sandi C., "Stress and cognition", Wiley Interdiscip Rev Cogn Sci. 2013 May;4(3):245-261. doi: 10.1002/wcs.1222. Epub 2013 Jan 22. PMID: 26304203.. https://pubmed.ncbi.nlm.nih.gov/26304203/
  • 79. Killgore WD., "Effects of sleep deprivation on cognition", Prog Brain Res. 2010;185:105-29. doi: 10.1016/B978-0-444-53702-7.00007-5. PMID: 21075236.. https://pubmed.ncbi.nlm.nih.gov/21075236/
  • 80. Ali SA, Begum T, Reza F., "Hormonal Influences on Cognitive Function", Malays J Med Sci. 2018 Jul;25(4):31-41. doi: 10.21315/mjms2018.25.4.3. Epub 2018 Aug 30. PMID: 30914845; PMCID: PMC6422548.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422548/
  • 81. Choudhary D, Bhattacharyya S, Bose S., "Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions", J Diet Suppl. 2017 Nov 2;14(6):599-612. doi: 10.1080/19390211.2017.1284970. Epub 2017 Feb 21. PMID: 28471731.. https://pubmed.ncbi.nlm.nih.gov/28471731/
  • 82. Dar NJ, MuzamilAhmad., "Neurodegenerative diseases and Withania somnifera (L.): An update.", J Ethnopharmacol. 2020 Jun 28;256:112769. doi: 10.1016/j.jep.2020.112769. Epub 2020 Mar 30. PMID: 32240781.. https://pubmed.ncbi.nlm.nih.gov/32240781/
  • 83. Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martínez A, Kreider RB., "Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis", J Funct Morphol Kinesiol. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. PMID: 33670194; PMCID: PMC8006238.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006238/
  • 84. GRAHAM BINDER, "Researchers with the College of AGNR study nutrient-packed microgreens", College of Agriculture & Natural Resources, September 6, 2012. https://agnr.umd.edu/news/mighty-microgreens
  • 85. GAO, "While Levels in Clothing Generally Appear to Be Low, Allergic Contact Dermatitis Is a Health Issue for Some People", United States Government Accountability Office, Report to Congressional Committees, August 2010. https://www.gao.gov/assets/gao-10-875.pdf
  • 86. Dongre S, Langade D, Bhattacharyya S., "Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study.", Biomed Res Int. 2015;2015:284154. doi: 10.1155/2015/284154. Epub 2015 Oct 4. PMID: 26504795; PMCID: PMC4609357.. https://pubmed.ncbi.nlm.nih.gov/26504795/
  • 87. Chauhan, S, Srivastava, MK, Pathak, AK., "Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial", Health Sci Rep. 2022; 5:e741. doi:10.1002/hsr2.741. https://onlinelibrary.wiley.com/doi/10.1002/hsr2.741
  • 88. Langade D, Thakare V, Kanchi S, Kelgane S., "Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study", J Ethnopharmacol. 2021 Jan 10;264:113276. doi: 10.1016/j.jep.2020.113276. Epub 2020 Aug 17. PMID: 32818573.. https://pubmed.ncbi.nlm.nih.gov/32818573/
  • 89. Abhijit Deshpande, Nushafreen Irani, Ratna Balkrishnan, Irin Rosanna Benny,, "A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults,", Sleep Medicine, Volume 72, 2020, Pages 28-36, ISSN 1389-9457, https://doi.org/10.1016/j.sleep.2020.03.012.. https://www.sciencedirect.com/science/article/abs/pii/S1389945720301246
  • 90. Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S, "Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study", Phytomedicine. 2000 Dec;7(6):463-9. doi: 10.1016/S0944-7113(00)80030-6. PMID: 11194174.. https://pubmed.ncbi.nlm.nih.gov/11194174/
  • 91. Rashad, N.M., Samir, G.M., "Prevalence, risks, and comorbidity of thyroid dysfunction: a cross-sectional epidemiological study", Egypt J Intern Med 31, 635–641 (2019). https://doi.org/10.4103/ejim.ejim_22_19. https://ejim.springeropen.com/articles/10.4103/ejim.ejim_22_19
  • 92. Durg S, Bavage S, Shivaram SB, "Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application", Phytother Res. 2020 May;34(5):1041-1059. doi: 10.1002/ptr.6589. Epub 2020 Jan 23. PMID: 31975514.. https://pubmed.ncbi.nlm.nih.gov/31975514/
  • 93. ASRM, American Society for Reproductive Medicine, "In approximately 40 percent of infertile couples, the male partner is either the sole cause or a contributing cause of infertility", Reproductivefacts.org/resources/infographic-gallery. https://www.reproductivefacts.org/resources/infographic-gallery/images/in-approximately-40-percent-of-infertile-couples-the-male-partner-is-either-the-sole-cause-or-a-contributing-cause-of-infertility/
  • 94. Tiwari S, Gupta SK, Pathak AK, "A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults", J Ethnopharmacol. 2021 May 23;272:113929. doi: 10.1016/j.jep.2021.113929. Epub 2021 Feb 15. PMID: 33600918.. https://pubmed.ncbi.nlm.nih.gov/33600918/
  • 95. Chandrasekhar K, Kapoor J, Anishetty S, "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults", Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022. PMID: 23439798; PMCID: PMC3573577. https://pubmed.ncbi.nlm.nih.gov/23439798/
  • 96. Mirjalili MH, Moyano E, Bonfill M, Cusido RM, Palazón J, "Steroidal lactones from Withania somnifera, an ancient plant for novel medicine", Molecules. 2009 Jul 3;14(7):2373-93. doi: 10.3390/molecules14072373. PMID: 19633611; PMCID: PMC6255378. https://pubmed.ncbi.nlm.nih.gov/19633611/
  • 97. Carnegie Mellon University, "Stress Contributes To Range Of Chronic Diseases, Review Shows", ScienceDaily. ScienceDaily, 10 October 2007. https://www.sciencedaily.com/releases/2007/10/071009164122.htm
  • 98. Bremner JD, "Does stress damage the brain?", Biol Psychiatry. 1999 Apr 1;45(7):797-805. doi: 10.1016/s0006-3223(99)00009-8. PMID: 10202566. https://pubmed.ncbi.nlm.nih.gov/10202566/
  • 99. Kalmbach DA, Anderson JR, Drake CL, "The impact of stress on sleep: Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders", J Sleep Res. 2018 Dec;27(6):e12710. doi: 10.1111/jsr.12710. Epub 2018 May 24. PMID: 29797753; PMCID: PMC7045300. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045300/
  • 100. National Institutes of Health, "Poor Sleep Linked With Higher Blood Sugar", newsinhealth.nih.gov/Health Capsule/ July 2022. https://newsinhealth.nih.gov/2020/07/poor-sleep-linked-higher-blood-sugar
  • 101. Winston D, Maimes S, "Adaptogens: Herbs for Strength, Stamina, and Stress Relief", Rochester: Inner Traditions/Bear & Co. Vol. 48. Rochester: Inner Traditions/Bear & Co; 2007; p. 53. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979308/#REF8
  • 102. Bhatnagar M, Sharma D, Salvi M, "Neuroprotective effects of Withania somnifera dunal.: A possible mechanism", Neurochem Res. 2009 Nov;34(11):1975-83. doi: 10.1007/s11064-009-9987-7. Epub 2009 May 15. PMID: 19444606. https://pubmed.ncbi.nlm.nih.gov/19444606/
  • 103. Salve J, Pate S, Debnath K, Langade D, "Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study", Cureus. 2019 Dec 25;11(12):e6466. doi: 10.7759/cureus.6466. PMID: 32021735; PMCID: PMC6979308. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979308/
  • 104. Gopukumar, K.Thanawala, S. Somepalli, V. Rao Sathyanaryana, T. S. Thamatam, V.B. Chauhan, S., "Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study", Evidence-Based Complementary and Alternative Medicine/ Volume 2021/Article ID 8254344. https://www.hindawi.com/journals/ecam/2021/8254344/
  • 105. Choudhary D, Bhattacharyya S, Bose S., "Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions", J Diet Suppl. 2017 Nov 2;14(6):599-612. doi: 10.1080/19390211.2017.1284970. Epub 2017 Feb 21. PMID: 28471731. https://pubmed.ncbi.nlm.nih.gov/28471731/
  • 106. Dar NJ, MuzamilAhmad, "Neurodegenerative diseases and Withania somnifera (L.): An update", J Ethnopharmacol. 2020 Jun 28;256:112769. doi: 10.1016/j.jep.2020.112769. Epub 2020 Mar 30. PMID: 32240781. https://pubmed.ncbi.nlm.nih.gov/32240781/
  • 107. LULU XIE, HONGYI KANG, QIWU XU, MICHAEL J. CHEN, YONGHONG LIAO, MEENAKSHISUNDARAM THIYAGARAJAN, JOHN O’DONNELL, DANIEL J. CHRISTENSEN, CHARLES NICHOLSON, JEFFREY J. ILIFF, TAKAHIRO TAKANO, RASHID DEANE, AND MAIKEN NEDERGAARD, "Sleep Drives Metabolite Clearance from the Adult Brain", SCIENCE 18 Oct 2013 Vol 342, Issue 6156 pp. 373-377 DOI: 10.1126/science.1241224. https://www.science.org/doi/10.1126/science.1241224
  • 108. Bhatnagar M, Sharma D, Salvi M, "Neuroprotective effects of Withania somnifera dunal.: A possible mechanism", Neurochem Res. 2009 Nov;34(11):1975-83. doi: 10.1007/s11064-009-9987-7. Epub 2009 May 15. PMID: 19444606. https://pubmed.ncbi.nlm.nih.gov/19444606/
  • 109. Baker C, Kirby JB, O'Connor J, Lindsay KG, Hutchins A, Harris M, "The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial", J Med Food. 2022 Aug 18. doi: 10.1089/jmf.2022.0042. Epub ahead of print. PMID: 35984870. https://pubmed.ncbi.nlm.nih.gov/35984870/
  • 110. Nayely Leyva-López, et al, "Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties", https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152729/
  • 111. S. Santoya et al, "Supercritical carbon dioxide extraction of compounds with antimicrobial activity from Origanum vulgare L.: determination of optimal extraction parameters", https://pubmed.ncbi.nlm.nih.gov/16496578/
  • 112. Snigdha Sacena et al, "Evaluation of Systemic Oxidative Stress in Patients with Premature Canities and Correlation of Severity of Hair Graying with the Degree of Redox Imbalance", https://pubmed.ncbi.nlm.nih.gov/32549695/
  • 113. Yunes Panahi et al, "Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial", https://pubmed.ncbi.nlm.nih.gov/25842469/
  • 114. Stephen C Barker & Phillip M Altman, "An ex vivo, assessor blind, randomised, parallel group, comparative efficacy trial of the ovicidal activity of three pediculicides after a single application - melaleuca oil and lavender oil, eucalyptus oil and lemon tea tree oil, and a "suffocation" pediculicide", https://bmcdermatol.biomedcentral.com/articles/10.1186/1471-5945-11-14
  • 115. C Hay et al, "Randomized trial of aromatherapy. Successful treatment for alopecia areata", https://pubmed.ncbi.nlm.nih.gov/9828867/
  • 116. "Synaptic Pruning", https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/synaptic-pruning
  • 117. CeJpeK, K, "“Antioxidant Activity in Variously Prepared Elderberry Foods and Supplements.”", Czech J. Food Sci. Vol. 27, 2009, Special Issue. https://www.agriculturejournals.cz/publicFiles/07578.pdf
  • 118. Porter RS, Bode RF, "A Review of the Antiviral Properties of Black Elder (Sambucus nigra L.) Products", Phytother Res. 2017 Apr;31(4):533-554. doi: 10.1002/ptr.5782. Epub 2017 Feb 15. PMID: 28198157..
  • 119. Deepak Langade, Subodh Kanchi, Jaising Salve, Khokan Debnath, and Dhruv Ambegaokar, "Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study", Cureus. 2019 Sep; 11(9): e5797. Published online 2019 Sep 28. doi: 10.7759/cureus.5797 PMCID: PMC6827862PMID: 31728244. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827862/
  • 120. Mohammad Hossein Mirjalili, Elisabeth Moyano, Mercedes Bonfill, Rosa M Cusido, Javier Palazón, "Steroidal lactones from Withania somnifera, an ancient plant for novel medicine", Molecules. 2009 Jul 3;14(7):2373-93. doi: 10.3390/molecules14072373.. https://pubmed.ncbi.nlm.nih.gov/19633611/
  • 121. Deepak Langade, Subodh Kanchi, Jaising Salve, Khokan Debnath, Dhruv Ambegaokar, "Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study", Cureus . 2019 Sep 28;11(9):e5797. doi: 10.7759/cureus.5797.. https://pubmed.ncbi.nlm.nih.gov/31728244/
  • 122. Biswajit Auddy, PhD1; Jayaram Hazra, PhD2; Achintya Mitra, MD2; Bruce Abedon, PhD3; Shibnath Ghosal, PhD1, "A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study", JANA Vol 11, No.1 2008. https://blog.priceplow.com/wp-content/uploads/2014/08/withania_review.pdf
  • 123. K Chandrasekhar, Jyoti Kapoor, Sridhar Anishetty, "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults", Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022.. https://pubmed.ncbi.nlm.nih.gov/23439798/
  • 124. Deepak Langade, Vaishali Thakare, Subodh Kanchi, Sunil Kelgane, "Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study", Randomized Controlled Trial J Ethnopharmacol. 2021 Jan 10;264:113276.. https://pubmed.ncbi.nlm.nih.gov/32818573/
  • 125. Abhijit Deshpandea, Nushafreen Irania, Ratna BalkrishnanaIrin, Rosanna Bennyb, "A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults", Sleep Medicine Volume 72, August 2020, Pages 28-36. https://www.sciencedirect.com/science/article/abs/pii/S1389945720301246
  • 126. Mahesh K. Kaushik ,Sunil C. Kaul, Renu Wadhwa,Masashi Yanagisawa, Yoshihiro Urade, "Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction", Published: February 16, 2017 https://doi.org/10.1371/journal.pone.0172508. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172508
  • 127. Mahesh K. Kaushik ,Sunil C. Kaul, Renu Wadhwa,Masashi Yanagisawa, Yoshihiro Urade, "Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction", Published: February 16, 2017 https://doi.org/10.1371/journal.pone.0172508. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172508
  • 128. Adrian L. Lopresti, PhD,a,b,∗ Stephen J. Smith, MA,a,b Hakeemudin Malvi, MBBS, MD,c and Rahul Kodgule, MBBSd, "An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract", Medicine (Baltimore). 2019 Sep; 98(37): e17186. Published online 2019 Sep 13. doi: 10.1097/MD.0000000000017186. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/#R20
  • 129. Adrian L. Lopresti, PhD,a,b,∗ Stephen J. Smith, MA,a,b Hakeemudin Malvi, MBBS, MD,c and Rahul Kodgule, MBBSd, "An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract", Medicine (Baltimore). 2019 Sep; 98(37): e17186. Published online 2019 Sep 13. doi: 10.1097/MD.0000000000017186. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/#R18
  • 130. Nicolas C. Nicolaides, Alexandros N. Vgontzas, Ilia Kritikou, George Chrousos Kenneth R Feingold, Bradley Anawalt, Alison Boyce, George Chrousos, Wouter W de Herder, Ketan Dhatariya, Kathleen Dungan, Jerome M Hershman, Johannes Hofland, Sanjay Kalra, Gregory Kaltsas, Christian Koch, Peter Kopp, Márta Korbonits, Christopher S Kovacs, Wendy Kuohung, Blandine Laferrère, Miles Levy, Elizabeth A McGee, Robert McLachlan, John E Morley, Maria New, Jonathan Purnell, Rakesh Sahay, Frederick Singer, Mark A Sperling, Constantine A Stratakis, Dace L Tren, Don P Wilson, editors., "HPA Axis and Sleep", In: Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. 2020 Nov 24.. https://pubmed.ncbi.nlm.nih.gov/25905298/
  • 131. Eva Fries, Lucia Dettenborn, Clemens Kirschbaum, "The cortisol awakening response (CAR): facts and future directions", Int J Psychophysiol. 2009 Apr;72(1):67-73. doi: 10.1016/j.ijpsycho.2008.03.014. Epub 2008 Sep 30.. https://pubmed.ncbi.nlm.nih.gov/18854200/
  • 132. Nicolas C. Nicolaides, Alexandros N. Vgontzas, Ilia Kritikou, George Chrousos Kenneth R Feingold, Bradley Anawalt, Alison Boyce, George Chrousos, Wouter W de Herder, Ketan Dhatariya, Kathleen Dungan, Jerome M Hershman, Johannes Hofland, Sanjay Kalra, Gregory Kaltsas, Christian Koch, Peter Kopp, Márta Korbonits, Christopher S Kovacs, Wendy Kuohung, Blandine Laferrère, Miles Levy, Elizabeth A McGee, Robert McLachlan, John E Morley, Maria New, Jonathan Purnell, Rakesh Sahay, Frederick Singer, Mark A Sperling, Constantine A Stratakis, Dace L Tren, Don P Wilson, editors., "HPA Axis and Sleep", In: Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. 2020 Nov 24.. https://pubmed.ncbi.nlm.nih.gov/25905298/
  • 133. Al Sunni A, Latif R., "Effects of chocolate intake on Perceived Stress; a Controlled Clinical Study", Int J Health Sci (Qassim). 2014 Oct;8(4):393-401. PMID: 25780358; PMCID: PMC4350893.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350893/
  • 134. Steptoe A, Gibson EL, Vuononvirta R, Williams ED, Hamer M, Rycroft JA, Erusalimsky JD, Wardle J., "The effects of tea on psychophysiological stress responsivity and post-stress recovery: a randomised double-blind trial", Psychopharmacology (Berl). 2007 Jan;190(1):81-9. doi: 10.1007/s00213-006-0573-2. Epub 2006 Sep 30. PMID: 17013636. https://pubmed.ncbi.nlm.nih.gov/17013636/
  • 135. "Calm Kit", https://www.gaiaherbs.com/products/calm-kit
  • 136. Hussain J, Cohen M., "Clinical Effects of Regular Dry Sauna Bathing: A Systematic Review", Evid Based Complement Alternat Med. 2018 Apr 24;2018:1857413. doi: 10.1155/2018/1857413. PMID: 29849692; PMCID: PMC5941775.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941775/
  • 137. Statista Research Department, "Digital device addiction among users in the United States as of September 2022, by stress level", https://www.statista.com. https://www.statista.com/statistics/1343810/us-users-addiction-digital-devices-by-stress-level/
  • 138. Singh KV, Gautam R, Meena R, Nirala JP, Jha SK, Rajamani P., "Effect of mobile phone radiation on oxidative stress, inflammatory response, and contextual fear memory in Wistar rat", Environ Sci Pollut Res Int. 2020 Jun;27(16):19340-19351. doi: 10.1007/s11356-020-07916-z. Epub 2020 Mar 24. PMID: 32212071.. https://pubmed.ncbi.nlm.nih.gov/32212071/
  • 139. Eric Suni, "Technology in the Bedroom", https://www.sleepfoundation.org/bedroom-environment/technology-in-the-bedroom
  • 140. Barton J, Rogerson M, "The importance of greenspace for mental health", BJPsych Int. 2017 Nov 1;14(4):79-81. doi: 10.1192/s2056474000002051. PMID: 29093955; PMCID: PMC5663018.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663018/
  • 141. Lee MS, Lee J, Park BJ, Miyazaki Y., "Interaction with indoor plants may reduce psychological and physiological stress by suppressing autonomic nervous system activity in young adults: a randomized crossover study", J Physiol Anthropol. 2015 Apr 28;34(1):21. doi: 10.1186/s40101-015-0060-8. PMID: 25928639; PMCID: PMC4419447.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419447/
  • 142. Alexander Panossian, Georg Wikman, "Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity", Pharmaceuticals 2010, 3(1), 188-224; https://doi.org/10.3390/ph3010188. https://www.mdpi.com/1424-8247/3/1/188
  • 143. Mirjalili MH, Moyano E, Bonfill M, Cusido RM, Palazón J., "Steroidal lactones from Withania somnifera, an ancient plant for novel medicine.", Molecules. 2009 Jul 3;14(7):2373-93. doi: 10.3390/molecules14072373. PMID: 19633611; PMCID: PMC6255378.. https://pubmed.ncbi.nlm.nih.gov/19633611/
  • 144. Sanjaya Chauhan,Manoj K. Srivastava,Anklesh K. Pathak, "Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial", 20 July 2022 https://doi.org/10.1002/hsr2.741. https://onlinelibrary.wiley.com/doi/10.1002/hsr2.741
  • 145. UT News, "Stress Hormone Blocks Testosterone’s Effects, Study Shows", The University of Texas at Austin. https://news.utexas.edu/2010/09/27/stress-hormone-blocks-testosterones-effects-study-shows/
  • 146. Centers for Disease Control and Prevention, "Data and Statistics", cdc.gov. https://www.cdc.gov/sleep/data_statistics.html
  • 147. Krishnan V, Collop NA, "Gender differences in sleep disorders", Curr Opin Pulm Med. 2006 Nov;12(6):383-9. doi: 10.1097/01.mcp.0000245705.69440.6a. PMID: 17053485.. https://pubmed.ncbi.nlm.nih.gov/17053485/
  • 148. Office of Communications, "How does inadequate sleep affect health?", National Institutes of Health. nichd.nih.gov/health/topics/sleep/conditioninfo/inadequate-sleep#
  • 149. Gorelick J, Rosenberg R, Smotrich A, Hanuš L, Bernstein N., "Hypoglycemic activity of withanolides and elicitated Withania somnifera", Phytochemistry. 2015 Aug;116:283-289. doi: 10.1016/j.phytochem.2015.02.029. Epub 2015 Mar 18. PMID: 25796090.. https://pubmed.ncbi.nlm.nih.gov/25796090/
  • 150. Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A, "Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study.", Evid Based Complement Alternat Med. 2013;2013:571420. doi: 10.1155/2013/571420. Epub 2013 Nov 28. PMID: 24371462; PMCID: PMC3863556.. https://pubmed.ncbi.nlm.nih.gov/24371462/
  • 151. Lopresti AL, Drummond PD, Smith SJ., "A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males", American Journal of Men’s Health. 2019;13(2). doi:10.1177/1557988319835985. https://journals.sagepub.com/doi/full/10.1177/1557988319835985
  • 152. American Psychological Association, "Stress in America", APA.org. https://www.apa.org/news/press/releases/stress/2022/march-2022-survival-mode
  • 153. Aviva USA, "Aviva survey finds financial situation is top stressor for men and links stress levels to weight gain", https://www.aviva.com/newsroom/news-releases/2012/06/usa-aviva-survey-finds-financial-situation-is-top-stressor-for-men-and-links-stress-levels-to-weight-gain-16940/